Essential papers in C. elegans
CSR-1 Pathway:
First papers on CSR-1 22G-RNAs function
-
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Claycomb et al., Cell. 2009 Oct 2;139(1):123-34 PMID:19804758 PDF
-
CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Van Wolfswinkel et al., Cell. 2009 Oct 2;139(1):135-48. PMID:19804759 PDF
Putative role of CSR-1 in translation inhibition
Role of CSR-1 in transcription
Anti-silencing role of CSR-1 in piRNA-mediated silencing
Slicer activity of CSR-1
Paper on EGO-1 (RdRP in CSR-1 pathway)
piRNAs and PRG-1:
Discovery and characterization of 21U-RNAs (later described as piRNAs)
First paper on 21U-RNAs by Bartel Lab
21U-RNAs are the C. elegans piRNAs
21U-RNAs in C. elegans male
Transcription and biogenesis of piRNAs
First papers that describe how 21U-RNAs/piRNAs are transcribed:
Factors involved in 21U-RNAs/piRNAs transcription/biogenesis
piRNA 3'end formation by PARN-1
piRNAs are 2'-O-methylated
Role of piRNAs in silencing transposons and single-copy transgenes
Role of piRNAs in germline mortality phenotype
RNAi-dependent and RNAi-indipendent H3K9 methylation:
Transgenerational RNAi-mediated H3K9 methylation
Antagonistic effect of H3K9 methylation and RNAi
RNAi and H3K9 methylation on endogenous loci
Role of H3K9 methylation in genome stability
H3K9 methylation and silencing of repetitive elements
Localization of H3K9 methylation domains in C. elegans germline
MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality. Weiser et al., Dev Cell 2017.
Nuclear RNAi:
First paper on nuclear Argonaute RNAi
Identification of other co-factors in nuclear RNAi
nuclear RNAi direct H3K27 methylation (a bit controversial)
New screening for Nuclear RNAi factors by Kennedy Lab