Essential papers in C. elegans

CSR-1 Pathway:

First papers on CSR-1 22G-RNAs function

  • The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Claycomb et al., Cell. 2009 Oct 2;139(1):123-34 PMID:19804758   PDF

  • CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Van Wolfswinkel et al., Cell. 2009 Oct 2;139(1):135-48. PMID:19804759   PDF

Putative role of CSR-1 in translation inhibition 

PMID: 22231398   PDF

Role of CSR-1 in transcription

PMID: 24360276   PDF

PMID: 24681887   PDF

Anti-silencing role of CSR-1 in piRNA-mediated silencing

PMID: 24360782   PDF

PMID: 24360783   PDF

PMID: 26279485   PDF

Slicer activity of CSR-1

PMID: 27020753   PDF

Paper on EGO-1 (RdRP in CSR-1 pathway)

PMID: 21396820   PDF

piRNAs and PRG-1:

Discovery and characterization of 21U-RNAs (later described as piRNAs)

First paper on 21U-RNAs by Bartel Lab

PMID: 17174894   PDF

21U-RNAs are the C. elegans piRNAs

PMID: 18571452   PDF

PMID: 18571451   PDF

21U-RNAs in C. elegans male

PMID: 18501605   PDF 

Transcription and biogenesis of piRNAs

First papers that describe how 21U-RNAs/piRNAs are transcribed:

PMID: 22819322   PDF

PMID: 23260138   PDF

Factors involved in 21U-RNAs/piRNAs transcription/biogenesis

PMID: 24696453   PDF

PMID: 24696457   PDF

PMID: 24696458   PDF

PMID: 25373775   PDF

piRNA 3'end formation by PARN-1

PMID: 26919432   PDF

piRNAs are 2'-O-methylated

PMID: 22548001   PDF

PMID: 22536158   PDF

PMID: 22829772   PDF

Role of piRNAs in silencing transposons and single-copy transgenes

PMID: 22738726   PDF

PMID: 22738724   PDF

PMID: 22700655   PDF

PMID: 22738725   PDF

PMID: 22850670   PDF

Role of piRNAs in germline mortality phenotype

PMID: 24767993   PDF

 

RNAi-dependent and RNAi-indipendent H3K9 methylation:

Transgenerational RNAi-mediated H3K9 methylation

PMID: 22231482   PDF

PMID: 22810588   PDF

Antagonistic effect of H3K9 methylation and RNAi

PMID: 28343968   PDF

RNAi and H3K9 methylation on endogenous loci

PMID: 28228846   PDF

PMID: 26779286   PDF

PMID: 25534009   PDF

Role of H3K9 methylation in genome stability

PMID: 27668659   PDF

H3K9 methylation and silencing of repetitive elements 

PMID: 28294943   PDF

Localization of H3K9 methylation domains in C. elegans germline

PMID: 20107519   PDF

MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality. Weiser et al., Dev Cell 2017.

PMID: 28535375   PDF

Nuclear RNAi:

First paper on nuclear Argonaute RNAi

PMID: 18653886   PDF

Follow up paper

PMID: 20543824   PDF

Identification of other co-factors in nuclear RNAi

PMID: 21901112   PDF

nuclear RNAi is heritable

PMID: 22106253   PDF

nuclear RNAi direct H3K27 methylation (a bit controversial)

PMID: 26365259   PDF

New screening for Nuclear RNAi factors by Kennedy Lab

PMID: 28533440   PDF