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Inheritance and maintenance of small RNA-mediated epigenetic effects.

Quarato P, Singh M, Bourdon LCecere G.

Bioessay. 2022 , 2100284.

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piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development.

Cornes E, Bourdon L, Singh M, Mueller F, Quarato P, Wernersson E, Bienko M, Li B, Cecere G.

Developmental Cell. 2022 Jan 24;57(2):180-196.e7. doi: 10.1016/j.devcel.2021.11.025. Epub 2021 Dec 17. PMID: 34921763.

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Featured in Developmental Cell Previews: Charlesworth AG, Nitschko V, Renaud MS, Claycomb JM. PIWI puts spermatogenesis in its place. Dev Cell. 2022 Jan 24;57(2):149-151. doi: 10.1016/j.devcel.2022.01.001. PMID: 35077678




Global Run-On sequencing to measure nascent transcription in C. elegans.

Quarato P, Cecere G.

STAR Protocols. 2021 Dec 4;2(4):100991. doi:10.1016/j.xpro.2021.100991. PMID: 34927098; PMCID: PMC8649397.

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A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection.

Singh M, Chazal M, Quarato P, Bourdon L, Malabat C, Vallet T, Vignuzzi M, van der Werf S, Behillil S, Donati F, Sauvonnet N, Nigro G, Bourgine M, Jouvenet N, Cecere G.

EMBO Reports. 2021 Dec 16:e54341. doi: 10.15252/embr.202154341. Epub ahead of print. PMID: 34914162.

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Histone variant H2A.Z regulates zygotic genome activation.

Ibarra-Morales D, Rauer M, Quarato P, Rabbani L, Zenk F, Schulte-Sasse M, Cardamone F, Gomez-Auli A, Cecere G, Iovino N.

Nature Communications. 2021 Dec 1;12(1):7002. doi:10.1038/s41467-021-27125-7. PMID: 34853314; PMCID: PMC8636486. 

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Collaboration with the Iovino Lab. We performed GRO-seq during zygotic genome activation in Drosophila embryos

Small RNAs in epigenetic inheritance: from mechanisms to trait transmission.

Cecere G.

FEBS Letters. 2021 Dec;595(24):2953-2977. doi:10.1002/1873-3468.14210. Epub 2021 Oct 29. PMID: 34671979.

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Featured as the issue cover.



Recombination-independent recognition of DNA homology for meiotic silencing in Neurospora crassa.

Rhoades N, Nguyen TS, Witz G, Cecere G, Hammond T, Mazur AK, Gladyshev E.

Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2108664118. doi: 10.1073/pnas.2108664118. PMID: 34385329; PMCID: PMC8379962.

Collaboration with the Eugene Gladyshev Lab.


Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis.

Singh M, Cornes E, Li B, Quarato P, Bourdon L, Dingli F, Loew D, Proccacia S, Cecere G.

Nature Communications. 2021 Jun 9;12(1):3492. doi: 10.1038/s41467-021-23615-w. PMID: 34108460; PMCID: PMC8190271.

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Featured in the Editor’s highlight collection.


Functional Characterization of the m6A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite.

Sinha A, Baumgarten S, Distiller A, McHugh E, Chen P, Singh M, Bryant JM, Liang J, Cecere G, Dedon PC, Preiser PR, Ralph SA, Scherf A.

mBio. 2021 Apr 27;12(2):e00661-21. doi: 10.1128/mBio.00661-21. PMID: 33906926; PMCID: PMC8092261.

A contribution from Meetali and Germano on ribo-seq to this interesting work from the Scherf lab.


Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos.

Quarato P, Singh M, Cornes E, Li B, Bourdon L, Mueller F, Didier C, Cecere G.

Nature Communications. 2021 Mar 4;12(1):1441. doi: 10.1038/s41467-021-21691-6. PMID: 33664268; PMCID: PMC7933186.

Free Online Article

Featured in the Editor’s highlight collection.




Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants.

Barucci G, Cornes E, Singh M, Li B, Ugolini M, Samolygo A, Didier C, Dingli F, Loew D, Quarato P, Cecere G.

Nature Cell Biology. 2020 Feb;22(2):235-245. doi: 10.1038/s41556-020-0462-7. Epub 2020 Feb 3. PMID: 32015436; PMCID: PMC7272227.

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Featured as the issue cover.









CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing.

Serrat X, Kukhtar D, Cornes E, Esteve-Codina A, Benlloch H, Cecere G, Cerón J.
PLoS Genetics. 2019 Oct 21;15(10):e1008464. doi: 10.1371/journal.pgen.1008464. PMID: 31634348; PMCID: PMC6830814.

Xenia Serrat from the Cerón Lab was a visiting student in our lab. This work is the result of such collaboration.



Germano's previous works



RNA Chromatin Immunoprecipitation (RNA-ChIP) in Caenorhabditis elegans.

Cecere G*, Grishok A.

Bio Protocols. 2014 Dec 20;4(24):e1358. doi: 10.21769/BioProtoc.1358. PMID: 29170745; PMCID: PMC5697774.

*Corresponding author

Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.

Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A.

Nature Structural Molecular Biology. 2014 Apr;21(4):358-65. doi: 10.1038/nsmb.2801. Epub 2014 Mar 30. PMID: 24681887; PMCID: PMC4068146.

Comment in Gene expression: RNAi as a global transcriptional activator. Nat Rev Mol Cell Biol. 2014. 


A nuclear perspective on RNAi pathways in metazoans.

Cecere G, Grishok A.

Biochim Biophys Acta. 2014 Mar;1839(3):223-33. doi: 10.1016/j.bbagrm.2013.11.009. Epub 2013 Dec 17. PMID: 24361586; PMCID: PMC3951611.




The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.

Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A.

Molecular Cell. 2013 Jun 27;50(6):894-907. doi: 10.1016/j.molcel.2013.06.002. PMID: 23806335; PMCID: PMC3784254.


The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.

Avgousti DC, Cecere G, Grishok A.

Molecular and Cellular Biology. 2013 Mar;33(5):999-1015. doi: 10.1128/MCB.01462-12. Epub 2012 Dec 21. PMID: 23263989; PMCID: PMC3623080.




Promoters recognized by forkhead proteins exist for individual 21U-RNAs.

Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A.

Molecular Cell. 2012 Sep 14;47(5):734-45. doi: 10.1016/j.molcel.2012.06.021. Epub 2012 Jul 19. PMID: 22819322; PMCID: PMC3444671.

(F1000 Prime Recommendation)




A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.

Mansisidor AR*, Cecere G*, Hoersch S, Jensen MB, Kawli T, Kennedy LM, Chavez V, Tan MW, Lieb JD, Grishok A.

PLoS Genetics. 2011 Sep;7(9):e1002299. doi:10.1371/journal.pgen.1002299. Epub 2011 Sep 29. PMID: 21980302; PMCID: PMC3183084.

*Co-first authors 




Quelling targets the rDNA locus and functions in rDNA copy number control.

Cecere G*, Cogoni C*.

BMC Microbiology. 2009 Feb 25;9:44. doi: 10.1186/1471-2180-9-44. PMID: 19243581; PMCID: PMC2650698.

*Co-corresponding authors

(Highly accessed articles) 




The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A.

Nolan T*, Cecere G*, Mancone C, Alonzi T, Tripodi M, Catalanotto C, Cogoni C.

Nucleic Acids Research. 2008 Feb;36(2):532-8. doi: 10.1093/nar/gkm1071. Epub 2007 Nov 29. PMID: 18048414; PMCID: PMC2241871.

*Co-first authors 

(F1000 Prime Recommendation) 



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